Piracetam.net (Australia & NZ) - Nootropics, Modafinil & more

  • Contact Us
  • About Us
  • About Us
  • Contact Us
  • facebook
  • twitter
  • instagram
  • youtube
  • dailymotion
  • tumblr
Search
Menu
  • Piracetam
    • Piracetam — The Original Nootropic
    • Is Piracetam Legal in Australia?
    • Piracetam stacks: More than the sum of their parts
    • Taking Choline with Piracetam
    • Piracetam vs Aniracetam: Which is Best?
    • Piracetam vs Modafinil
    • Close
  • Modafinil
    • Modafinil – The Definitive Resource (2023)
    • The Ultimate Guide to Buying MODAFINIL Online
    • Best Modafinil Deals with Bitcoin or Other Cryptocurrencies (Altcoins)
    • 8 Frequently Asked Questions About Modafinil for Sleep Apnea
    • Buying Modafinil Online? Get the Latest Discounts on Here
    • Unlocking the Secrets of Modafinil: How the Popular Wakefulness Drug Works Its Magic and Offers New Therapeutic Possibilities
    • Off-label applications for Modafinil
    • Modafinil scientifically proven to improve cognitive performance
    • Guide to Getting the Most out of Modafinil for Studying
    • How to Stop Modafinil-induced Anxiety
    • Modafinil – For Staying Awake and Alert
    • Piracetam vs Modafinil
    • Does Modafinil Really Work? New Study Says Yes.
    • Adrafinil – A Cost-Effective Way to Stay Alert
    • History of Modafinil
    • Close
  • Aniracetam
    • Aniracetam: For Enhancing Cognition and Mood
    • Piracetam vs Aniracetam: Which is Best?
    • Close
  • Choline
    • Choline: A Cognitive Enhancer and an Essential Nutrient
    • Taking Choline with Piracetam
    • CDP-choline: Citicoline Provides a Boost in Focus & Memory
    • Alpha-GPC: More than Just a Choline Supplement
    • Close
  • Alpha Brain
    • Alpha Brain: a Nootropic Stack All in One
    • Alpha Brain – To Buy or Not To Buy?
    • Getting the Most out of Alpha Brain
    • Onnit Releases new Alpha Brain Instant
    • Close
  • Nootropics Articles
    • What Exactly Are Nootropics?
    • Nootropics for Beginners: What, Why, and How
    • The Longevity Formula: An Insight into Dr David Sinclair’s Anti-Aging Regimen
    • Nootropics and Gaming: Power Up Your Performance in the Virtual World Down Under
    • Tips for Maximising Caffeine Supplementation
    • Rhodiola Extracts: Rosavin vs. Salidrosides
    • Gotu Kola: The Brain Herb
    • How and Why You Should Feed Your Brain With Phospholipids
    • Using Bacopa monnieri for Cognitive Performance
    • The Nootropic Benefits of Ginseng
    • Nootropics for ADHD
    • The Cognitive Benefits of L-Theanine
    • Racetams: An Overview
    • Psilocybin: Microdosing For Nootropic Effects
    • Huperzine A – the Newest Study Aid?
    • CILTEP – Retain Information Better, for Longer
    • Vinpocetine: An Oxygen Boost to the Brain
    • Studying with Nootropics
    • Phenylpiracetam: A Powerful Racetam with Unique Properties
    • Pramiracetam: For Extreme Cognitive Power
    • Oxiracetam: A Powerful Alternative
    • Noopept: A Superstrong Cognition and Mood Booster
    • Natural Cognitive Enhancers
    • The Top 5 Science-Backed Benefits of Reishi Mushrooms
    • Ashwagandha: India’s Oldest Superherb
    • 5 Brain-Boosting Benefits Of Cordyceps Mushroom
    • Lion’s Mane Mushroom for Cognitive Enhancement
    • Top Five Nootropics from the Bulletproof Company
    • Lithium for Brain Health – History, Benefits, Supplementation, Side Effects & More
    • Close
  • Forum / Q&A

Leave a Comment

The Longevity Formula: An Insight into Dr David Sinclair’s Anti-Aging Regimen

The Longevity Formula: An Insight into Dr David Sinclair’s Anti-Aging Regimen
Image of Dr. David Sinclair in March 2020, captured by Editor5627. This image is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
Dr. David Sinclair: A Leading Figure in Anti-Aging Research

Harvard longevity expert Dr David Sinclair has long been a thought leader in the anti-aging field. Renowned for his expertise in the epigenetics of aging, NAD+ metabolism, and sirtuins, Sinclair’s scientific insights have been widely disseminated via his best-selling book, “Lifespan,” and numerous podcast interviews. This article provides a comprehensive overview of the 13 supplements and drugs that form Sinclair’s personal anti-aging stack, along with their rationale, dosage, and an analysis of their potential benefits and limitations.

A Delve into the Longevity Regimen

1. Nicotinamide Mononucleotide (NMN)

Dosed at 1g per day, Nicotinamide Mononucleotide (NMN) is a precursor to NAD+—a critical element for cellular energy production. However, NAD+ levels decline with age, which makes NMN supplementation potentially valuable. Sinclair opts for NMN over alternatives like Niacin due to its solid evidence base.

2. Resveratrol

Resveratrol, controversial due to some inconsistent findings, is a key part of Sinclair’s daily intake. This compound activates sirtuins, proteins that protect our DNA and regulate inflammation. Sinclair takes 1g of resveratrol daily with coconut yogurt to enhance absorption. Pterostilbene, a compound found in blueberries, is suggested as a more potent alternative.

3. Quercetin

A potent senolytic, Quercetin is known for removing damaged cells and promoting cellular energy. Taken at 500mg per day, this flavonoid also activates anti-aging pathways and has numerous health benefits, from insulin sensitivity to anti-allergic properties.

4. Fisetin

Fisetin, dubbed as Quercetin’s younger cousin, is another potent senolytic. This compound also supports hair growth, neurogenesis, and cardioprotection. The recommended dose is 500mg per day.

5. Spermidine

Spermidine, a novel compound, supercharges autophagy, a cellular cleansing process. Early studies show a potential 25% increase in lifespan in mice. Sinclair takes 1mg of spermidine per day.

Pharmaceutical Intervention in the Longevity Equation

6. Metformin

Metformin, a diabetes drug, is known to mimic the benefits of fasting, activate longevity pathways, and provide anti-cancer benefits. The recommended dose is 800mg at night. However, it’s important to note potential risks including B vitamin deficiency, GI issues, and hypoglycemia.

7. Vitamin D3

Vitamin D3 is essential unless you are exposed to ample sunlight daily. It enhances immunity, supports cardiovascular health, and has been shown to lengthen lifespan in animal models. Sinclair takes approximately 5,000 IU of Vitamin D3 daily.

8. Vitamin K2

Vitamin K2, paired with Vitamin D3, ensures proper calcium absorption and prevents arterial calcification. Sinclair’s dose is approximately 120 mcg per day.

9. Statin

Sinclair includes Statins in his regimen due to a family history of heart disease. However, their use is controversial due to potential adverse effects on mitochondrial function and muscle health. The specific drug and dose are not specified.

10. Low-dose Aspirin

A common anti-inflammatory and painkiller, Sinclair takes 83mg of Aspirin daily. Notably, Aspirin is also a potent cancer-prevention tool and can upregulate dopamine synthesis.

11. Alpha-lipoic Acid (ALA)

This potent antioxidant may slow aging under certain circumstances. Sinclair takes Alpha-lipoic Acid (ALA) to combat oxidative stress, but the specific dosage is not specified. If you decide to take ALA, consider using Na-R-ALA or R-ALA Cyclodextrin for enhanced bioavailability.

12. Coenzyme Q10 (CoQ10)

Essential for mitochondrial function, Coenzyme Q10 (CoQ10) enhances ATP energy production, particularly within the cardiovascular system. The specific dosage Sinclair takes is not specified. Ubiquinol is recommended as an alternative due to its higher bioavailability.

13. TMG (Trimethylglycine or Betaine)

Lastly, Sinclair takes between 500 to 1000mg of Trimethylglycine (TMG) daily. TMG provides additional methyl groups, which are consumed by the kidney while processing NMN.

In Summary

In the quest for longevity, Sinclair’s regimen offers a thoughtfully curated approach to supplement intake. It’s important to remember, however, that while this regimen may work for Sinclair, everyone’s needs and responses to supplements may vary. Always consult with a qualified physician prior to starting any dietary supplement or drug regimen.

Disclaimer

This article provides an overview of the personal anti-aging regimen of Dr David Sinclair, a scientist and not a medical doctor. The information herein is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The specifics of this regimen should not be interpreted as recommendations for anyone else’s personal use.

Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition, dietary adjustments, or the use of dietary supplements or drugs. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.

Filed Under: Mental Health, Nootropics

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Modafinil

Buy Modafinil Online

Find us on Facebook

Forum

  • Best place to buy Modafinil online for Australian? asked by Roland
  • Modafinil Discount Coupon/Voucher Code? asked by modafinil lover
  • Piracetam and Zoloft? asked by Anonymous
  • Starting Piracetam (again) this week, attack dose or no attack dose, thoughts? asked by Tommy
  • Nootropics for a 90yr old male? asked by Anonymous

Recent Comments

  • Andrew Huang on Methylene Blue for Memory and Energy Enhancement
  • Soloman on Getting the Most out of Alpha Brain
  • Matt on Getting the Most out of Alpha Brain
  • MAC on Getting the Most out of Alpha Brain
  • Thatcher on How to Stop Modafinil-induced Anxiety
Content Protection by DMCA.com

This website uses cookies by default. You may opt-out if desired by clicking settings.Cookie settingsACCEPT
Copyright © 2011-2023 Piracetam.net • Privacy Policy • Terms of Service • Disclosure Policy Disclaimer: No statements made on this informational website have been reviewed by any government agencies or associations. The products, nutritional supplements and natural based herbal and food-based constituents mentioned on this site are not intended to diagnose, treat, cure, alleviate or prevent any diseases or illnesses. All content on this site is the opinions of their respective authors who do not claim or profess to be medical professionals providing medical advice, except where clearly stated. This website is solely for the purpose of providing the opinions of the authors and content contributors. You should consult with your doctor or qualified healthcare professional before you start taking any dietary supplements or engage in activities mentioned on this site. This website is supported by different affiliates and we receive a paid commission on various products mentioned throughout. Any and all trademarks, logos brand names and service marks displayed on this website are the registered or unregistered Trademarks of their respective owners.

This website uses cookies by default. You may opt-out if desired by clicking settings. Cookie settingsACCEPT
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT