Piracetam.net (Australia & NZ) - Nootropics, Modafinil & more

  • Contact Us
  • About Us
  • About Us
  • Contact Us
  • facebook
  • twitter
  • instagram
  • dailymotion
  • tumblr
Search
Menu
  • Piracetam
    • Piracetam — The Original Nootropic
    • Is Piracetam Legal in Australia?
    • Piracetam stacks: More than the sum of their parts
    • Taking Choline with Piracetam
    • Piracetam vs Aniracetam: Which is Best?
    • Piracetam vs Modafinil
    • Close
  • Modafinil
    • Modafinil – The Definitive Resource (2023)
    • The Ultimate Guide to Buying MODAFINIL Online
    • Best Modafinil Deals with Bitcoin or Other Cryptocurrencies (Altcoins)
    • Buying Modafinil Online? Get the Latest Discounts on Here
    • Off-label applications for Modafinil
    • Modafinil scientifically proven to improve cognitive performance
    • Guide to Getting the Most out of Modafinil for Studying
    • How to Stop Modafinil-induced Anxiety
    • Modafinil – For Staying Awake and Alert
    • Piracetam vs Modafinil
    • Does Modafinil Really Work? New Study Says Yes.
    • Adrafinil – A Cost-Effective Way to Stay Alert
    • History of Modafinil
    • Close
  • Aniracetam
    • Aniracetam: For Enhancing Cognition and Mood
    • Piracetam vs Aniracetam: Which is Best?
    • Close
  • Choline
    • Choline: A Cognitive Enhancer and an Essential Nutrient
    • Taking Choline with Piracetam
    • CDP-choline: Citicoline Provides a Boost in Focus & Memory
    • Alpha-GPC: More than Just a Choline Supplement
    • Close
  • Alpha Brain
    • Alpha Brain: a Nootropic Stack All in One
    • Alpha Brain – To Buy or Not To Buy?
    • Getting the Most out of Alpha Brain
    • Onnit Releases new Alpha Brain Instant
    • Close
  • Nootropics Articles
    • What Exactly Are Nootropics?
    • Nootropics for Beginners: What, Why, and How
    • Tips for Maximising Caffeine Supplementation
    • Rhodiola Extracts: Rosavin vs. Salidrosides
    • Gotu Kola: The Brain Herb
    • How and Why You Should Feed Your Brain With Phospholipids
    • Using Bacopa monnieri for Cognitive Performance
    • The Nootropic Benefits of Ginseng
    • Nootropics for ADHD
    • The Cognitive Benefits of L-Theanine
    • Racetams: An Overview
    • Psilocybin: Microdosing For Nootropic Effects
    • Huperzine A – the Newest Study Aid?
    • CILTEP – Retain Information Better, for Longer
    • Vinpocetine: An Oxygen Boost to the Brain
    • Studying with Nootropics
    • Phenylpiracetam: A Powerful Racetam with Unique Properties
    • Pramiracetam: For Extreme Cognitive Power
    • Oxiracetam: A Powerful Alternative
    • Noopept: A Superstrong Cognition and Mood Booster
    • Natural Cognitive Enhancers
    • The Top 5 Science-Backed Benefits of Reishi Mushrooms
    • Ashwagandha: India’s Oldest Superherb
    • 5 Brain-Boosting Benefits Of Cordyceps Mushroom
    • Lion’s Mane Mushroom for Cognitive Enhancement
    • Top Five Nootropics from the Bulletproof Company
    • Lithium for Brain Health – History, Benefits, Supplementation, Side Effects & More
    • Close
  • Forum / Q&A

Leave a Comment

Sulbutiamine – a Nootropic Supplement to Improve Concentration and Reduce Fatigue

Sulbutiamine – a Nootropic Supplement to Improve Concentration and Reduce Fatigue
Sulbutiamine is a synthetic derivative of thiamine which was discovered in Japan as part of an effort to develop useful thiamine derivatives.

Sulbutiamine is a derivative of Vitamin B1 or thiamine. Thiamine has long been recognised as an essential vitamin which contributes to energy, brain function and performance. The potential of thiamine supplementation to improve human performance means that it has been the subject of extensive research, with some promising results. Sulbutiamine, in particular, is an analogue – an equivalent or precursor – to naturally occurring vitamin B1 which has a slightly different uptake and mechanism of action, and which has exciting applications in nootropic medicine; sulbutiamine can help improve brain function.[1]Braintropic. (2019). Sulbutiamine – Review of Benefits, Effects, Dosage, and More | Braintropic. [online] Available at https://www.braintropic.com/nootropics/sulbutiamine/ [Accessed 14 Dec. 2019]. 

>> Looking to Buy Sulbutiamine? Click here to see our recommended sellers.

What are the benefits of taking sulbutiamine? 

Photo of man writing on his notebook
Sulbutiamine can be used by the brain to improve concentration, mental, and possibly physical performance.

Sulbutiamine increases the amount of thiamine that can be used by the brain to improve concentration, mental, and possibly physical performance. For a healthy person, sulbutiamine can enhance memory and improve functional performance in mental and physical tasks.[2]Micheau, J., Durkin, T.P., Destrade, C., Rolland, Y. and Jaffard, R., 1985. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology Biochemistry and Behavior, 23(2), pp.195-198. Sulbutiamine can also be used to treat asthenia[3] Sciencedirect.com. (2019). Asthenia – an overview | ScienceDirect Topics. [online] Available at https://www.sciencedirect.com/topics/medicine-and-dentistry/asthenia [Accessed 14 Dec. 2019].  in those already experiencing symptoms of fatigue and weakness with no identifiable cause or who have suffered fatigue and weakness following an illness.[4]Tiev KP, Cabane J, Imbert JC. [Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo] Rev Med Interne. 1999;20(10):912–918. There is an increasing body of evidence linking sulbutiamine to reduced fatigue and has even improved feelings of weakness in people with multiple sclerosis (MS).[5]Sevim, S., Kaleağası, H. and Taşdelen, B., 2017. Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. Multiple sclerosis and related disorders, 16, pp.40-43.[6]Pillbuys.com. (2019). [online] Available at https://pillbuys.com/research/Sulbutiamine/22.pdf [Accessed 14 Dec. 2019]. With improved brain function and concentration comes a significant improvement in short and long-term memory, and after successful animal studies[7]Micheau, J., Durkin, T.P., Destrade, C., Rolland, Y. and Jaffard, R., 1985. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology Biochemistry and Behavior, 23(2), pp.195-198. sulbutiamine is now being trialled in people suffering Alzheimer’s disease and other forms of dementia, with the potential to change lives.[8]Gibson, G.E., Hirsch, J.A., Fonzetti, P., Jordon, B.D., Cirio, R.T. and Elder, J., 2016. Vitamin B1 (thiamine) and dementia. Annals of the New York Academy of Sciences, 1367(1), p.21. 

Are there any risks associated with sulbutiamine?

Photo of man holding his head while using his laptop
A small number of people taking sulbutiamine have reported nausea, headache, tiredness, and inability to sleep.

The most stringent studies to have been done on sulbutiamine so far list some possible side effects, including headache and gastrointestinal disturbances,[9]Alraek T, Lee MS, Choi TY, Cao H, Liu J (October 2011). “Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review“. BMC Complementary and Alternative Medicine. 11: 87. doi:10.1186/1472-6882-11-87 and so it is recommended that sulbutiamine should be started at a low dose to monitor for side effects in the individual. Nootropic ‘stacking’ – the practice of combining different supplements or medications for optimum effect, should only be used after trialling each supplement individually for effect. Some people have reported sleeplessness after taking sulbutiamine, but as its duration of action is only around five hours,[10]Braintropic. (2019). Sulbutiamine – Review of Benefits, Effects, Dosage, and More | Braintropic. [online] Available at https://www.braintropic.com/nootropics/sulbutiamine/ [Accessed 14 Dec. 2019]. this can be managed by avoiding sulbutiamine supplements within five hours of bedtime. 

The regulation of sulbutiamine varies from country to country, and in Australia is not yet recognised by the Therapeutic Goods Administration[11]Therapeutic Goods Administration (TGA). (2019). Australian regulatory guidelines for complementary medicines (ARGCM). [online] Available at: https://www.tga.gov.au/sites/default/files/australian-regulatory-guidelines-complementary-medicines-argcm.pdf [Accessed 14 Dec. 2019]. which governs medications.[12]Ghosh, D., Skinner, M. and Ferguson, L.R., 2006. The role of the Therapeutic Goods Administration and the Medicine and Medical Devices Safety Authority in evaluating complementary and alternative medicines in Australia and New Zealand. Toxicology, 221(1), pp.88-94. Sulbutiamine is well recognised and used as a mainstream nootropic supplement in some other countries, most notably in France. 

How should I take sulbutiamine? 

Photo of woman filling up a glass of water.
The recommended dosage of sulbutiamine is 200mg one to three times a day.

The current recommended dosage to achieve the intended effects of sulbutiamine without significant risk of side effects is 200mg one to three times a day,[13]5 Sulbutiamine (Arcalion) Benefits + Dosage, Side Effects – SelfHacked. (2019). Retrieved 14 December 2019, from https://selfhacked.com/blog/sulbutiamine/ and it is readily available in tablets of this strength. Sulbutiamine is a fat-soluble substance, and its uptake in the body may be increased by taking it with a meal. As a lipophilic – fat-soluble – compound, it can cross the blood-brain barrier and directly affect those parts of the brain known to be associated with memory,[14]Bizot, J.C., Herpin, A., Pothion, S., Pirot, S., Trovero, F. and Ollat, H., 2005. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(6), pp.928-935. fatigue and functional ability.[15]Van Reeth, O., 1999. Pharmacologic and therapeutic features of sulbutiamine. Drugs Today (Barc), 35(3), pp.187-192. 

Sulbutiamine is not thought to be addictive as it has no psychotropic effect and no components which cause chemical dependency. Sulbutiamine is recommended for only short-term use, and as always, it is important to consult a doctor before beginning any new supplements, especially for those with pre-existing conditions or who take regular medications.

Buy Sulbutiamine Online Review Comparison Table

Product Company Quantity Price Country Website

Sulbutiamine Capsules
Nootropics Depot
90 - 180 pills (200 mg) $23.99 - $36.99
Worldwide, US, AU
Visit Website >>

Sulbutiamine Capsules
Pure Nootropics
60 pills (200 mg) $12.99
Worldwide, US, AU
Visit Website >>

Sulbutiamine Capsules
Double Wood
90 pills (200 mg) $19.95
Worldwide, US, AU
Visit Website >>

Originally posted on December 16, 2019, last updated on March 9, 2023.

References

[+]

References

↑1, ↑10 Braintropic. (2019). Sulbutiamine – Review of Benefits, Effects, Dosage, and More | Braintropic. [online] Available at https://www.braintropic.com/nootropics/sulbutiamine/ [Accessed 14 Dec. 2019].
↑2, ↑7 Micheau, J., Durkin, T.P., Destrade, C., Rolland, Y. and Jaffard, R., 1985. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology Biochemistry and Behavior, 23(2), pp.195-198.
↑3 Sciencedirect.com. (2019). Asthenia – an overview | ScienceDirect Topics. [online] Available at https://www.sciencedirect.com/topics/medicine-and-dentistry/asthenia [Accessed 14 Dec. 2019].
↑4 Tiev KP, Cabane J, Imbert JC. [Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo] Rev Med Interne. 1999;20(10):912–918.
↑5 Sevim, S., Kaleağası, H. and Taşdelen, B., 2017. Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. Multiple sclerosis and related disorders, 16, pp.40-43.
↑6 Pillbuys.com. (2019). [online] Available at https://pillbuys.com/research/Sulbutiamine/22.pdf [Accessed 14 Dec. 2019].
↑8 Gibson, G.E., Hirsch, J.A., Fonzetti, P., Jordon, B.D., Cirio, R.T. and Elder, J., 2016. Vitamin B1 (thiamine) and dementia. Annals of the New York Academy of Sciences, 1367(1), p.21.
↑9 Alraek T, Lee MS, Choi TY, Cao H, Liu J (October 2011). “Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review“. BMC Complementary and Alternative Medicine. 11: 87. doi:10.1186/1472-6882-11-87
↑11 Therapeutic Goods Administration (TGA). (2019). Australian regulatory guidelines for complementary medicines (ARGCM). [online] Available at: https://www.tga.gov.au/sites/default/files/australian-regulatory-guidelines-complementary-medicines-argcm.pdf [Accessed 14 Dec. 2019].
↑12 Ghosh, D., Skinner, M. and Ferguson, L.R., 2006. The role of the Therapeutic Goods Administration and the Medicine and Medical Devices Safety Authority in evaluating complementary and alternative medicines in Australia and New Zealand. Toxicology, 221(1), pp.88-94.
↑13 5 Sulbutiamine (Arcalion) Benefits + Dosage, Side Effects – SelfHacked. (2019). Retrieved 14 December 2019, from https://selfhacked.com/blog/sulbutiamine/
↑14 Bizot, J.C., Herpin, A., Pothion, S., Pirot, S., Trovero, F. and Ollat, H., 2005. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(6), pp.928-935.
↑15 Van Reeth, O., 1999. Pharmacologic and therapeutic features of sulbutiamine. Drugs Today (Barc), 35(3), pp.187-192.

Filed Under: Nootropics

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Alpha Brain by Onnit

Ready to break through mental fog? Try a one-week, free trial of Onnit's best-selling nootropic, Alpha Brain.pixel

Find us on Facebook

Forum

  • Best place to buy Modafinil online for Australian? asked by Roland
  • Modafinil Discount Coupon/Voucher Code? asked by modafinil lover
  • Piracetam and Zoloft? asked by Anonymous
  • Starting Piracetam (again) this week, attack dose or no attack dose, thoughts? asked by Tommy
  • Nootropics for a 90yr old male? asked by Anonymous

Recent Comments

  • Andrew Huang on Methylene Blue for Memory and Energy Enhancement
  • Soloman on Getting the Most out of Alpha Brain
  • Matt on Getting the Most out of Alpha Brain
  • MAC on Getting the Most out of Alpha Brain
  • Thatcher on How to Stop Modafinil-induced Anxiety
Content Protection by DMCA.com

This website uses cookies by default. You may opt-out if desired by clicking settings.Cookie settingsACCEPT
Copyright © 2011-2023 Piracetam.net • Privacy Policy • Terms of Service • Disclosure Policy Disclaimer: No statements made on this informational website have been reviewed by any government agencies or associations. The products, nutritional supplements and natural based herbal and food-based constituents mentioned on this site are not intended to diagnose, treat, cure, alleviate or prevent any diseases or illnesses. All content on this site is the opinions of their respective authors who do not claim or profess to be medical professionals providing medical advice, except where clearly stated. This website is solely for the purpose of providing the opinions of the authors and content contributors. You should consult with your doctor or qualified healthcare professional before you start taking any dietary supplements or engage in activities mentioned on this site. This website is supported by different affiliates and we receive a paid commission on various products mentioned throughout. Any and all trademarks, logos brand names and service marks displayed on this website are the registered or unregistered Trademarks of their respective owners.

This website uses cookies by default. You may opt-out if desired by clicking settings. Cookie settingsACCEPT
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT